Why the study?
Does diazoxide-induced hypotension reduce cerebral blood flow in hypertensive rats?
Population
Rats with renal and spontaneous hypertension
Comparison
Diazoxide (5 mg/kg, i.v. bolus) vs Control hypertensive rats not given diazoxide
Design
Preclinical
Follow-up
2 to 2.5 hours
Authors
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Raises caution for cerebral ischemia with diazoxide in hypertensive models; leaves open translation to human practice.
Does diazoxide-induced hypotension reduce cerebral blood flow in hypertensive rats?
Acute diazoxide-induced hypotension in hypertensive rats reduces cerebral blood flow below the lower limit of autoregulation, potentially leading to ischaemic brain damage.
Barry et al. (1983) studied this question.
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