August 1, 1990AJP Regulatory Integrative and Comparative Physiology

Relationship between thirst and diazoxide-induced hypotension in rats

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Why the study?

Does diazoxide-induced hypotension stimulate thirst in conscious rats, and is it mediated by angiotensin II?

Population

Conscious rats with indwelling arterial and venous catheters

Comparison

Diazoxide with or without captopril or… vs Controls (baseline or without captopril)

Design

Preclinical

Authors

MEMark D. EveredUniversity of Cambridge

Discussion

Member takes

Implication

Reinforces angiotensin II mediation of thirst during hypotension in rats; leaves open translation to human physiology or therapy.

Structured PICO

Does diazoxide-induced hypotension stimulate thirst in conscious rats, and is it mediated by angiotensin II?

Population

Conscious rats with indwelling arterial and venous catheters

Intervention

Diazoxide (bolus iv injections 5-50 mg/kg) with or without captopril (100 mg/kg sc) or angiotensin II iv infusion

Comparator

Controls (baseline or without captopril)

Outcome

Mean arterial pressure (MAP) reduction and water intake (drinking)surrogate

Hypotension potently stimulates thirst in rats, a response mediated by angiotensin II.

Cite This Study

Mark D. Evered (1990) studied this question.

synapsesocial.com/papers/6a8164328c6be3b56fc437fa https://doi.org/10.1152/ajpregu.1990.259.2.r362

View Full Paper

Ask AI

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Relationship between thirst and diazoxide-induced hypotension in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship between thirst and diazoxide-induced hypotension in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider