Diazoxide Therapy: Use and Risks

Comments1 October 1976Diazoxide Therapy: Use and RisksWILLIAM J. MROCZEK, M.D., F.A.C.C., WON RO LEE, M.D.WILLIAM J. MROCZEK, M.D., F.A.C.C.Search for more papers by this author, WON RO LEE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-4-529 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent paper by Kanada and associates (1) describing an angina-like syndrome after diazoxide therapy is of concern to all physicians who treat hypertensive crises. We wish to comment on the high prevalence of diazoxide-induced angina-like side effects reported by Kanada and colleagues and to relate our recent experience with fatal myocardial infarction in a patient who received diazoxide.The frequent occurrence of angina-like symptoms after diazoxide administration is contrary to our experience and to that of other investigators (2, 3). Frequently patients complain of a sensation of internal warmth located in the thorax and abdomen. Symptoms...References1. KANADAKANADAHUTCHINSON SDR: Angina-like syndrome with diazoxide therapy for hypertensive crisis. Ann Intern Med 84:696-699, 1976 LinkGoogle Scholar2. MROCZEKDAVIDOVGAVRILOVICH WML: The value of aggressive therapy in the hypertensive patient with azotemia Circulation 40:893-904, 1969 CrossrefMedlineGoogle Scholar3. MILLERGIFFORDHUMPHREY WRD: Management of severe hypertension with intravenous injections of diazoxide. Am J Cardiol 24:870-875, 1969 CrossrefMedlineGoogle Scholar4. KUMARDASTOORROBAYO GFJ: Side effects of diazoxide. JAMA 235:275-276, 1976 CrossrefMedlineGoogle Scholar1. GOODMANGILMAN LA: The Pharmacological Basis of Therapeutics, 5th ed. New York, Macmillan Co., 1975, p. 833 Google Scholar1. KUMARDASTOORROBAYO GFJ: Side effects of diazoxide. JAMA 235:275-276, 1976 CrossrefMedlineGoogle Scholar1. KOCH-WESER J: Hypertensive emergencies. N Engl J Med 290:211-214, 1974 CrossrefMedlineGoogle Scholar2. HURST J (editor) : The Heart, 3rd ed. New York, McGraw-Hill Co., 1974, pp. 1242-1243 Google Scholar3. STRAUSSWELT ML (editors): Diseases of the Kidney, 2nd ed. Boston, Little, Brown and Co., 1971, p. 254 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Georgetown University Medical Division D.C. General Hospital Washington, D.C. 20003 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPeripheral edemaHypertensive emergencies and urgenciesBor und spezielle BorverbindungenGENETIC STUDIES OF HYDATIDIFORM MOLESHAZARDS OF INTRAVENOUS DIAZOXIDEBlood pressure reduction by incremental infusion of labetalol in patients with severe hypertension.Use of a simulation model to study the acute haemodynamic effects of diazoxide in manLABETALOL IN HYPERTENSIONTreatment for Hypertensive CrisisJ. BROOKS WATT, M.D.Hazards in Antihypertension TherapyRUSSELL L. BERDOFF, M.D., RICHARD L. CHALAL, M.D., MICHAEL MADDEN 1 October 1976Volume 85, Issue 4Page: 529-531KeywordsMyocardial infarctionThorax Issue Published: 1 October 1976 PDF downloadLoading ...