Key result
Systemic inflammation is linked to impaired right ventricular reserve in HFpEF, but this association is correlational and does not establish a causal mechanism.
Design
Editorial
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This letter highlights the methodological limitations in inferring a mechanistic link between systemic inflammation and impaired right ventricular reserve in patients with HFpEF based solely on observational data.
Dear Editor,We read with great interest a prospective, observational single-center study done by Mondellini et al. in which they examined systemic inflammation and exercise haemodynamics in patient...
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Faiz et al. (2026) studied this question. Systemic inflammation is linked to impaired right ventricular reserve in HFpEF, but this association is correlational and does not establish a causal mechanism.
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