The hexapeptide I-ILeu-Ser-Phe (NO2)-Nle-Ala-Leu-Ome is proposed as a reference for proteolytic activity determinations of chymosin (rennin).This peptide which is readily hydrolyzed by the enzyme contains a spectroscopic probe Phe (NO~) which facilitates routine determination of enzyme activity.Specific proteolytic activity has been measured for various purified and commercial enzyme preparations and compared to their clotting activity.
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Raymond et al. (1973) studied this question.
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