Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria

This is the authors' abstract. We don't add key points for this paper.

Two unusual normonoterpenoid indole alkaloids rauvomine A ( 1 ) and rauvomine B ( 2 ), together with two known compounds peraksine ( 3 ) and alstoyunine A ( 4 ), were isolated from the aerial parts of Rauvolfia vomitoria . The structures with absolute configurations of 1 and 2 were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations. Compound 2 is a novel C 18 normonoterpenoid indole alkaloid with a substituted cyclopropane ring that forms an unusual 6/5/6/6/3/5 hexcyclic rearranged ring system. The plausible biogenetic pathways of 1 and 2 were proposed. Compound 2 exhibited significant anti-inflammatory activity.