Key result
Severe aortic stenosis pressure overload can mimic cardiac amyloidosis on multimodality imaging, confounding noninvasive diagnosis.
Why the study?
Cardiac amyloidosis is increasingly recognized in older patients with severe aortic stenosis, but advanced pressure-overload remodeling can produce overlapping imaging features that confound noninvasive diagnosis.
Advanced pressure-overload remodeling in extremely severe aortic stenosis can produce imaging features on multimodality imaging that overlap with and mimic cardiac amyloidosis, confounding noninvasive diagnosis.
Answers are grounded in this paper and cite their sources.
Requires caution interpreting amyloid-like imaging in extreme aortic stenosis; extends remodeling phenotypes and leaves open need for confirmatory testing.
Cardiac amyloidosis is increasingly recognized in older patients with severe aortic stenosis, yet advanced pressure-overload remodeling can produce overlapping imaging features that confound noninvasive diagnosis.
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Kim et al. (2026) studied this question. Extremely severe aortic stenosis with advanced pressure-overload remodeling can mimic cardiac amyloidosis on multimodality imaging, confounding noninvasive diagnosis.
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