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This study examined the correlation between circulating catecholamine levels and ventricular vulnerability during psychological stress in conscious dogs.
The correlation between circulating catecholamines and ventricular vulnerability during psychologic stress was examined in conscious dogs. The repetitive extra-systole (RE) threshold was used to assess vulnerability to ventricular fibrillation. Exposure of the animals to a stressful sling environment compared to that of nonstressful cage setting resulted in a significant 41% (P < 0.01) reduction in the RE threshold. Plasma levels of norepinephrine and epinephrine increased twofold (P < 0.05) and fourfold (P < 0.01), respectively. It is concluded that the elevation in circulating catecholamine levels correlates closely with enhanced ventricular vulnerability during psychologic stress and that the model for psychologic stress employed results in substantial increases in plasma catecholamine levels which is in large part due to release of epinephrine from the adrenal medulla.
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Liang et al. (1979) studied Preclinical cardiovascular safety pharmacology (non-human primates and beagle dogs) and Phase 1 lymphoid malignancies. Telemetry-based unrestrained cardiovascular monitoring (evaluating AMG 319 and AMG 337) vs. Restraint-based snapshot cardiovascular monitoring (surface ECG and tail cuff HDO) and vehicle control was evaluated on Detection of drug-induced QTc interval prolongation (AMG 319) and mean arterial blood pressure reduction (AMG 337) (MD 67 ms (AMG 319 100 mg/kg QTc prolongation at 2h via telemetry); MD -29 mmHg (AMG 337 30 mg/kg MAP via telemetry), p=<0.05).
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