Key result
High baseline TyG-BRI is linked to ~45% higher incident CVD risk.
Why the study?
The associations of baseline levels and changes in the triglyceride glucose-body roundness index (TyG-BRI) with incident CVD needed investigation in European and Asian cohorts.
Does a high baseline level or persistently high trajectory of the Triglyceride Glucose-Body Roundness Index (TyG-BRI) increase the risk of incident cardiovascular disease in European and Asian adult cohorts?
Cohort (n=426,433)
Yes
Does a high baseline level or persistently high trajectory of the Triglyceride Glucose-Body Roundness Index (TyG-BRI) increase the risk of incident cardiovascular disease in European and Asian adult cohorts?
Both elevated baseline levels and persistently high longitudinal trajectories of the Triglyceride Glucose-Body Roundness Index (TyG-BRI) are independently associated with an increased risk of incident cardiovascular disease across European and Asian populations.
The aim of this study was to investigate the association of baseline and changes of TyG‐BRI with incident CVD based on the UK Biobank and China Health and Retirement Longitudinal Study (CHARLS). A total of 418,510 and 7923 individuals from the UK Biobank and CHARLS were included in Analysis 1 (baseline TyG‐BRI with CVD risk). In Analysis 2 (change in TyG‐BRI with CVD risk), a total of 11,682 and 4637 participants were included in Cox proportional hazard models. We found participants with the highest baseline TyG‐BRI level were associated with increased risk of incident CVD in UK Biobank (HR = 1.45, 95% CI: 1.39–1.52) and CHARLS (HR = 1.35, 95% CI: 1.13–1.61). Multivariable‐adjusted restricted cubic spline analyses presented positive linear associations between TyG‐BRI and CVD risk. Compared to persistently low levels of TyG‐BRI (Class 1), those with persistently high levels (Class 3: 1.23 (1.02–1.49) and 1.42 (1.11–1.55); Class 4: 1.48 (1.17–1.87) and 1.45 (1.16–2.28); Class 5: 2.58 (1.86–3.58) and 1.63 (1.16–2.28) for UK Biobank and CHARLS) in follow‐up were associated with increased risks of incident CVD. In conclusion, a high baseline TyG‐BRI level and different changes in TyG‐BRI level are associated with increased risks of incident CVD.
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Han et al. (2026) conducted a cohort in Cardiovascular diseases (CVD) (n=426,433). High baseline and persistently elevated Triglyceride Glucose-Body Roundness Index (TyG-BRI) vs. Lowest baseline or persistently low TyG-BRI levels (Class 1) was evaluated on Incident cardiovascular disease (CVD) (HR 1.45, 95% CI 1.39-1.52). High baseline TyG-BRI increased incident CVD risk in both the UK Biobank (HR 1.45, 95% CI 1.39-1.52) and CHARLS (HR 1.35, 95% CI 1.13-1.61) cohorts.
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