Key result
Epicardial fat volume is linked to ~9% higher odds of non-calcified plaque per 10 cm³.
Why the study?
Data regarding the association between epicardial adipose tissue and cardiovascular disease among HIV-infected persons were limited.
Cross-Sectional (n=250)
Blinded outcome assessment
Yes
Answers are grounded in this paper and cite their sources.
Supports further study of epicardial fat in HIV; hypothesis-generating and should not yet change practice.
Little data exist regarding the association of epicardial adipose tissue (EAT) and cardiovascular disease among HIV-infected persons. Among 213 HIV-infected men, there was a significant association between protease inhibitor use and increasing EAT volume. EAT was significantly associated with coronary artery calcium greater than 100. The elevated coronary artery disease risk in HIV-infected men may be partially explained by EAT associated with protease inhibitor use.
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Crum‐Cianflone et al. (2012) conducted a cross-sectional in HIV infection and subclinical coronary artery disease (n=250). HIV infection and epicardial fat volume vs. HIV-negative controls was evaluated on Epicardial fat volume (cm³) and its association with non-calcified coronary plaque presence (per 10 cm³ increase in epicardial fat) (OR 1.09, 95% CI 1.01-1.18, p=0.028). Epicardial fat volume was higher in people with HIV vs controls and independently associated with non-calcified coronary plaque.
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