Survey on Usage of Non-steroidal Anti-inflammatory Drugs after Off-pump Coronary Artery Bypass Grafting, and Prevention of Postoperative Infections

Owing to the possibility of postoperative infections after off-pump coronary artery bypass grafting (OPCAB),early mobilization is a major aim of postoperative management.Postoperative infections and other major postoperative complications can pose a serious clinical problem.In view of this,using retrospective analysis,we investigated the number of times a non-steroidal anti-inflammatory drug (NSAID) was used up to postoperative day 3,as well as the statuses of progress of cardiac rehabilitation and dietary intake on postoperative day 3 in patients undergoing primary OPCAB (N=2citation=39)between April 2008 and November 2009.In addition,to investigate the relevance of changing Cefazolin (CEZ) to another drug in preventing postoperative infections,each patient was assigned to one of the following 2 groups : those treated with CEZ,both before and after surgery (CEZ non-replacement group) ; and those treated with antibiotics other than CEZ after surgery (CEZ replacement group).We found that the rates for accomplishment of cardiac rehabilitation step 1 and intake of more than 30 percent of dietary intake on postoperative day 3 increased as frequency of NSAID use until postoperative day 3 increased.Furthermore,significant differences were noted for number of times an NSAID was used each day until postoperative day 3,cardiac rehabilitation step and postoperative dietary intake between the CEZ non-replacement group and CEZ replacement group.These results indicate that active NSAID use was effective in achieving early cardiac rehabilitation,increasing dietary intake after OPCAB as well as in preventing postoperative infections.