Adult Visceral Adiposity and Lung Function: A Triangulation Study across Chinese, Korean and US Cohorts

This is the authors' abstract. We don't add key points for this paper.

This study investigates whether visceral adiposity is causally associated with impaired lung function in adulthood, and whether systolic blood pressure mediates part of this effect. We triangulate evidence across four modules: (A) age-stratified cross-sectional analyses in KNHANES 2007–2019 and NHANES 2007–2012 (including FeNO as a mechanistic marker of type-2 airway inflammation); (B) within-person longitudinal analysis of peak expiratory flow (PEF) change in CHARLS 2011/2013/2015; (C) two-sample trans-ancestry Mendelian randomization using BioBank Japan exposure instruments and East-Asian-stratified lung function GWAS summary statistics (Shrine et al., 2023); (D) mechanistic localization by colocalization and SMR using East Asian eQTL/pQTL resources (MAEEA, HGVD, Nagahama, jMorp). The study does not claim a full life-course design; the 6–39 year segment in NHANES is treated as hypothesis-generating.