Key result
CMR parametric mapping differentiates benign cardiac tumor subtypes using native T1 and ECV values.
Why the study?
The application of cardiovascular magnetic resonance parametric mapping for characterizing and differentiating benign cardiac tumor subtypes remains underexplored.
Does cardiovascular magnetic resonance (CMR) parametric mapping improve the characterization and differentiation of benign cardiac tumor subtypes in patients undergoing surgical resection?
Observational (n=64)
Does cardiovascular magnetic resonance (CMR) parametric mapping improve the characterization and differentiation of benign cardiac tumor subtypes in patients undergoing surgical resection?
CMR parametric mapping, particularly extracellular volume (ECV) and native T1 mapping, significantly differentiates benign cardiac tumor subtypes, adding diagnostic value to traditional CMR prior to surgical resection.
Background The application of parametric mapping as a standard cardiovascular magnetic resonance (CMR) sequence in cardiac tumors remains underexplored. Purpose To assess the additional value of CMR parametric mapping in characterizing benign cardiac tumors and differentiating tumor subtypes. Methods This retrospective study included patients underwent CMR (with parametric mapping sequences) before surgical resection of suspected cardiac tumors between January 2019 and December 2024. The postoperative pathology was the criterion for determining benign tumor subtype. The parametric mapping such as native T1, post T1, and extracellular volume (ECV) values were measured for tumors. Differences in parametric mapping between tumor subtypes were analyzed using analysis of variance (ANOVA) and Brown-Forsythe test. Results Eventually 64 pathologically confirmed benign cardiac tumors (mean age: 36.7 ± 25.3 years; 37 males, 27 females) were included. The native T1 mapping and ECV values were statistically significant in Brown-Forsythe test and ANOVA among different tumor types (p=0.016 and p < 0.01), while no statistically significant difference was found in post T1 mapping values between groups (p = 0.319). The native T1 mapping values ranged from 150 ms (epidermoid cyst) to 1730 ms (hemangioma). The mean ECVs of myxomas, fibromas, hemangiomas, lipomas, rhabdomyomas, schwannomas, epidermoid cyst and angioleiomyolipoma were 51%, 91%, 62%, 5%, 44%, 67%, 52% and 16%, respectively. Conclusion CMR parametric mapping, particularly ECV, enables differentiation of benign cardiac tumors with high reproducibility. These findings support the additional role of quantitative CMR techniques to traditional CMR to improve tumor characterization and clinical decision making.
No takes yet. Share an insight, caveat, or question.
Zheng et al. (2026) conducted an observational in Benign cardiac tumors (n=64). Cardiovascular magnetic resonance (CMR) parametric mapping (native T1, post T1, and extracellular volume [ECV]) vs. Postoperative histopathology (reference standard across different benign tumor subtypes) was evaluated on Differences in native T1, post T1, and extracellular volume (ECV) values across benign cardiac tumor subtypes (p=0.016 (native T1) and <0.01 (ECV)). CMR parametric mapping significantly differentiated benign cardiac tumor subtypes using native T1 (p=0.016) and ECV (p<0.01), with mean ECV ranging from 5% in lipomas to 91% in fibromas.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: