Effects of herbs and spices on blood pressure

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) (n=202). Intervention: Dietary food group intakes (including red meat, nuts and oily seeds, and fish) vs. Healthy controls without MASLD (TE <288 dB/m). Primary outcome: Presence of Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) associated with red meat intake (OR 1.013, 95% CI 1.001-1.025, p=0.03).

Q: What does this research mean for the field?

Red meat intake is associated with an increased likelihood of metabolic dysfunction-associated steatotic liver disease (MASLD), whereas consumption of fish and nuts is associated with a reduced risk. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Amanda Appathurai; Markandeya Jois; Jessica Radcliffe

doi:10.1097/hjh.0000000000001952

October 9, 2018Journal of Hypertension

Effects of herbs and spices on blood pressure

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Why the study?

Literature suggests some herbs and spices have cardiovascular benefits such as decreasing blood pressure, but existing evidence across normotensive, pre-hypertensive, and hypertensive populations is inconsistent.

Key Points

To evaluate evidence from randomized controlled trials examining the effects of herbs and spices on blood pressure across normotensive, pre-hypertensive, and hypertensive individuals.
Systematically searched Ovid Medline, Embase, Biological Abstracts, CINAHL, and the Cochrane Collaboration.
Identified and analyzed nine randomized controlled trials meeting the inclusion and exclusion criteria.
Statistically significant blood pressure reductions were reported in three of the nine included trials overall.
Significant reductions occurred in one of two trials involving hypertensive participants and two of six trials involving pre-hypertensive participants.
The single trial evaluating normotensive participants demonstrated no change in blood pressure.

Study Design

Type

Case-Control (n=202)

Multicenter

No

PICO

P

Population

202 adults in the United Kingdom (168 patients with clinically diagnosed MASLD and 34 healthy controls without significant steatosis or fibrosis on transient elastography) assessed cross-sectionally using the EPIC-Norfolk food frequency questionnaire.

E

Exposure / Comparator

Dietary food group intakes (including red meat, nuts and oily seeds, and fish) vs Healthy controls without MASLD (TE <288 dB/m)

O

Primary Outcome

Presence of Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) associated with red meat intake — OR 1.013 (1.001-1.025), p=0.03

Main Result

Odds Ratio: 1.013 (95% CI 1.001–1.025)

Absolute Event Rate: 0.99% vs 0.83%

p-value: p=0.03

Limitations

Potential errors in portion size estimation due to assumptions made when deconstructing composite dishes from the EPIC-FFQ
Inability to individually assess cooked weight changes for each ingredient from standard recipes
Inability to distinguish between dietary under-reporting and intentional energy restriction or post-diagnosis dietary changes among MASLD patients
Significant baseline differences in age, sex ratio, and BMI between MASLD and control groups alongside a small control cohort size (n=34)

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Implication

Review reveals that certain herbs and spices reduce blood pressure in hypertensive populations, suggesting potential cardiovascular benefits without inducing hypotension in healthy individuals.

Abstract

: Hypertension is a major risk factor for cardiovascular disease, affecting 1 billion people worldwide. Literature suggests some herbs and spices have cardiovascular benefits, such as decreasing blood pressure; yet evidence is inconsistent. This article reviewed randomized controlled trials investigating effects of herbs and spices on blood pressure in normotensive, pre-hypertensive and hypertensive participants. Ovid Medline, Embase, Biological abstracts, CINAHL and Cochrane Collaboration were systematically searched. After inclusion and exclusion criteria were applied, nine articles were included for analysis. Overall, three of the nine studies reported statistically significant results, including one of the two studies on hypertensive participants and two of the six studies on pre-hypertensive participants. The remaining study was conducted on normotensive participants and reported no change in blood pressure. There is evidence to suggest certain herbs and spices can reduce blood pressure in a hypertensive and pre-hypertensive population and may not induce hypotension in a normotensive population.

Discussion

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Cite This Study

Appathurai et al. (2018) conducted a case-control in Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) (n=202). Dietary food group intakes (including red meat, nuts and oily seeds, and fish) vs. Healthy controls without MASLD (TE <288 dB/m) was evaluated on Presence of Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) associated with red meat intake (OR 1.013, 95% CI 1.001-1.025, p=0.03).

synapsesocial.com/papers/6adf93cbc80181b0188ec445 https://doi.org/10.1097/hjh.0000000000001952

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Effects of herbs and spices on blood pressure

Key Points

Study Design

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effects of herbs and spices on blood pressure

Key Points

Study Design

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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