Key result
Obesity and insulin resistance are linked to diastolic dysfunction and early HFpEF markers in women.
Why the study?
The clinical, laboratory, and instrumental features of diastolic dysfunction and HFpEF in obese women required investigation.
What are the clinical, laboratory, and echocardiographic features of diastolic dysfunction and HFpEF in obese women compared to controls?
Observational (n=80)
What are the clinical, laboratory, and echocardiographic features of diastolic dysfunction and HFpEF in obese women compared to controls?
In women aged 25-65, obesity and associated dyslipidemia and insulin resistance correlate significantly with echocardiographic markers of diastolic dysfunction (reduced E/A ratio, increased E/e' index, LV wall thickening), highlighting the utility of echocardiography in early HFpEF detection.
Metabolic screening may flag diastolic risk in obese women; leaves open whether targeting dyslipidemia or insulin resistance alters HFpEF outcomes.
This study is devoted to the investigation of clinical, laboratory, and instrumental features of diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) in obese women. A total of 80 women aged 25–65 years were examined, including 40 obese patients and 40 controls.Laboratory assessments included lipid profile, glucose, and insulin levels. Echocardiography and ECG were used as instrumental methods.The results showed a significant increase in signs of diastolic dysfunction in obese women. A reduced E/A ratio, increased E/e’ index, and left ventricular wall thickening were identified as early markers of HFpEF development. Metabolic disorders, particularly dyslipidemia and insulin resistance, showed a positive correlation with impaired diastolic function (p<0.05). In conclusion, obesity negatively affects cardiac diastolic function and contributes to the development of HFpEF. Echocardiographic parameters play an important role in the early detection of this condition.
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Qudratillayeva Sadoqat (2026) conducted an observational in Diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) in obesity (n=80). Obesity vs. Non-obese controls was evaluated on Signs of diastolic dysfunction and early markers of HFpEF (reduced E/A ratio, increased E/e' index, left ventricular wall thickening) (p=<0.05). Obesity and associated dyslipidemia and insulin resistance significantly correlated with impaired cardiac diastolic function and early HFpEF markers in women (p<0.05).
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