Key result
Higher Aggregate Index of Systemic Inflammation (AISI) was associated with increased odds of elevated cTnT (OR 1.30; 95% CI 1.10-1.55; P=0.003) and CK-MB (OR 1.09; P=0.01) in CHD patients.
Why the study?
The Aggregate Index of Systemic Inflammation (AISI) is a potential cardiovascular risk indicator, but its association with contemporaneous myocardial injury in patients with coronary heart disease (CHD) remained unclear.
Is the Aggregate Index of Systemic Inflammation (AISI) associated with elevated myocardial injury markers (cTnT and CK-MB) in patients with coronary heart disease?
Observational
No
Is the Aggregate Index of Systemic Inflammation (AISI) associated with elevated myocardial injury markers (cTnT and CK-MB) in patients with coronary heart disease?
Elevated Aggregate Index of Systemic Inflammation (AISI) is independently and nonlinearly associated with elevated myocardial injury biomarkers (particularly cTnT) in patients with coronary heart disease, suggesting utility as a simple adjunctive risk marker.
Answers are grounded in this paper and cite their sources.
AISI elevation was associated with higher odds of cTnT rise; hypothesis-generating for inflammation in myocardial injury and requires prospective validation.
The Aggregate Index of Systemic Inflammation (AISI) is a potential cardiovascular risk indicator. Its association with contemporaneous myocardial injury in coronary heart disease (CHD) patients remains unclear. To explore the association between AISI and elevated myocardial injury markers and evaluate its discriminatory performance. In this single-centre retrospective study of consecutive CHD patients, AISI was calculated at admission. The patients were assessed at admission and before coronary angiography. Elevated cTnT was defined as >0.014 ng/mL and elevated CK-MB as >24 U/L. Logistic regression, subgroup analyses, ROC curves, and restricted cubic splines (RCS) were used. Significant differences across AISI tertiles were observed in adverse profiles. In multivariable-adjusted models, each unit increase in continuous AISI was associated with higher odds of elevated cTnT (OR = 1.30, 95% CI: 1.10, 1.55, p = 0.003) and elevated CK-MB (OR = 1.09, 95% CI: 1.02,1.17, p = 0.01). Compared with T1, T3 showed a significantly increased risk of elevated cTnT (OR = 3.14, 95% CI: 1.93,5.12, p < 0.01). Subgroup analyses revealed that AISI was more strongly associated with cTnT elevation in patients aged <70 years and in men, while the association with CK-MB was more evident in women and those aged ≥70 years. ROC analysis demonstrated moderate predictive value for cTnT (AUC = 0.72, 95% CI: 0.69, 0.75) and limited value for CK-MB (AUC = 0.65). RCS identified a nonlinear relationship with cTnT (P for nonlinearity = 0.0016), with an inflection point at 212.41. Elevated AISI is independently associated with myocardial injury biomarkers in CHD patients, particularly for cTnT elevation, with a nonlinear threshold effect near 212.4. This association varies by age and sex, suggesting that AISI may serve as a simple, cost-effective adjunctive marker for identifying CHD patients at risk of myocardial injury.
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Liu et al. (2026) conducted an observational in Coronary heart disease. Aggregate Index of Systemic Inflammation (AISI) vs. Lower AISI (per unit decrease or lowest tertile T1) was evaluated on Elevated cardiac troponin T (cTnT >0.014 ng/mL) (OR 1.30, 95% CI 1.10-1.55, p=0.003). Higher Aggregate Index of Systemic Inflammation (AISI) was associated with increased odds of elevated cTnT (OR 1.30; 95% CI 1.10-1.55; P=0.003) and CK-MB (OR 1.09; P=0.01) in CHD patients.
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