Key result
Higher admission AISI predicts ~3% greater acute stent thrombosis and mortality risk after STEMI PCI.
Why the study?
Acute stent thrombosis after primary PCI for STEMI is uncommon but often fatal, prompting evaluation of the Aggregate Index of Systemic Inflammation as a predictor of acute stent thrombosis and in-hospital mortality.
Does the Aggregate Index of Systemic Inflammation (AISI) predict acute stent thrombosis and in-hospital mortality in STEMI patients undergoing primary PCI?
Cohort (n=3,055)
Does the Aggregate Index of Systemic Inflammation (AISI) predict acute stent thrombosis and in-hospital mortality in STEMI patients undergoing primary PCI?
Odds Ratio: 1.03 (95% CI 1.02–1.05)
Admission AISI is a rapid, low-cost risk marker that independently predicts acute stent thrombosis and early death after primary PCI for STEMI.
AISI may aid post-PCI risk stratification in STEMI; leaves open whether it improves outcomes or warrants targeted interventions in prospective trials.
Acute stent thrombosis (ST) after primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI) is uncommon but often fatal. We evaluated whether the Aggregate Index of Systwemic Inflammation (AISI) predicts acute ST and in-hospital mortality. In this retrospective cohort, 3055 consecutive STEMI patients underwent pPCI with stent implantation. Admission AISI was calculated as (neutrophils × monocytes × platelets)/lymphocytes. Multivariable logistic regression identified independent predictors; receiver operating characteristic (ROC) analysis assessed discrimination for acute ST. Acute ST occurred in 76 patients (2.5%) and was associated with higher in-hospital mortality (15.8% vs 3.8%, P < .001). AISI was higher in patients with acute ST (1314.2 vs 689.7, P < .001) and independently predicted acute ST (OR 1.03, 95% CI 1.02-1.05). AISI showed moderate discrimination area under the curve (AUC) 0.720; cut-off 904.97; sensitivity 64.2%; specificity 64.3%). Higher AISI was also independently associated with in-hospital mortality (OR 1.05, P < .001). Admission AISI is independently associated with acute ST and early death after pPCI for STEMI, supporting its use as a rapid, low-cost risk marker pending prospective validation.
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Özkan et al. (2026) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=3,055). Aggregate Index of Systemic Inflammation (AISI) was evaluated on Acute stent thrombosis (OR 1.03, 95% CI 1.02-1.05). Higher admission Aggregate Index of Systemic Inflammation independently predicted acute stent thrombosis (OR 1.03; 95% CI 1.02-1.05) and in-hospital mortality after primary PCI for STEMI.
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