Aggregate index of systemic inflammation as a new prognostic marker in patients with coronary artery disease undergoing PCI

This article aim is to assess the association between the aggregate index of systemic inflammation (AISI) and long-term outcomes of coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI). 3482 patients are divided into the higher group (AISI ≥ 366) and the lower group (AISI < 366) according to cut-off value of AISI. The mean follow-up time was 37.59 ± 22.24 months. The primary endpoint includes all-cause mortality (ACM) and cardiac mortality (CM) and secondary endpoints include major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs). The results show that there are statistically significant differences in primary endpoint incidence. The incidence of ACM is 6.6% in higher group and 2.6% in lower group (P < 0.001) while the incidence of CM is 4.1% in higher group and 1.7% in lower group (P < 0.001). Cox regression analysis shows that the risk of ACM was increased to 2.298 times (HR = 2.298, 95% CI: 1.595-3.310, P < 0.001) and the risk of CM was increased to 2.160 times (HR = 2.160, 95% CI: 1.358-3.436, P = 0.001) in the higher group. Therefore, AISI is an independent predictor for CAD patients after PCI.