Key result
Inhaled nickel and sulfur dioxide are linked to reduced stroke volume in Aral Sea residents.
Why the study?
The influence of autonomic homeostasis on the cardiovascular system status of residents of the Aral Sea region needed investigation.
Does chronic environmental exposure to inhaled chemical pollutants in the Aral Sea ecological zones impair autonomic homeostasis and hemodynamic parameters compared to a control region in residents with and without cardiovascular disease?
Cross-Sectional (n=6,984)
Yes
Does chronic environmental exposure to inhaled chemical pollutants in the Aral Sea ecological zones impair autonomic homeostasis and hemodynamic parameters compared to a control region in residents with and without cardiovascular disease?
Chronic inhalation of environmental toxicants in the Aral Sea region is associated with heightened central autonomic nervous system strain and dose-dependent alterations in systolic blood volume and vascular resistance.
Answers are grounded in this paper and cite their sources.
Nickel and sulfur dioxide exposure may reduce systolic volume in Aral Sea CVD patients; leaves open causal effects and mitigation benefits.
The influence of autonomic homeostasis on the cardiovascular system of residents of the Aral Sea region was investigated. The study included residents of cities located in the “disaster zone,” the “crisis zone,” and the “pre-crisis ecological zone.” The control group consisted of residents of the settlement of Atasu without cardiovascular diseases (CVDs). Individuals with prenosological conditions showed increased strain on central regulatory functions and a reduced functional measure of systolic blood volume (SV), accompanied by increased activity of the sympathetic (AMo) and parasympathetic (Mo, HF) divisions of the autonomic nervous system, as well as an elevated stress index (SI). These findings indicated the predominance of central regulatory mechanisms over autonomous mechanisms. According to the study results, individuals with cardiovascular pathology showed a 1 mg increase in nickel accumulation. Sulfur dioxide accumulation was associated with a decrease in systolic blood volume, whereas increased copper levels were associated with an increase in stroke volume.
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Battakova et al. (2026) conducted a cross-sectional in Cardiovascular diseases and autonomic homeostasis disorders in environmentally stressed regions (n=6,984). Environmental inhalation exposure to chemical pollutants (nickel, sulfur dioxide, copper, zinc, cobalt, iron, nitrogen dioxide) vs. Residents of the control settlement Atasu was evaluated on Systolic blood volume (stroke volume) and heart rate variability indices of autonomic regulation. Inhaled nickel and sulfur dioxide reduced systolic blood volume by 1.65 mL and 1.3 mL respectively in Aral Sea residents with cardiovascular disease, while copper increased it by 1.92 mL.
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