Key result
High-normal blood pressure linked to significant impairment in sinoatrial autonomic regulation.
Why the study?
Subjects in the upper-normal range of arterial pressure have excess cardiovascular risk, suggesting impaired autonomic regulation might be implicated before hypertension develops.
Are noninvasive markers of cardiac and vascular autonomic regulation altered in subjects with high-normal arterial pressure levels?
Population
300 subjects with arterial pressure from 90/60 to 210/120 mm Hg divided into 3 groups of 100 each
Comparison
Subjects with low-normal, high-normal, and hypertensive arterial pressure levels
Design
Observational study using spectral analysis of RR interval and systolic arterial pressure variability
Authors
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Autonomic changes may precede hypertension; extends cross-sectional observations but leaves open causal role and clinical utility.
Observational (n=300)
Are noninvasive markers of cardiac and vascular autonomic regulation altered in subjects with high-normal arterial pressure levels?
Impairment in cardiac autonomic regulation is detectable in subjects with high-normal blood pressure, preceding the onset of overt arterial hypertension.
Lucini et al. (2002) conducted an observational in Arterial hypertension (n=300). High-normal arterial pressure vs. Normal arterial pressure was evaluated on Markers of cardiac and vascular autonomic regulation (spectral analysis of RR interval and systolic arterial pressure variability). High-normal arterial pressure (average systolic 133 mm Hg) was associated with significant alterations in markers of sinoatrial regulation compared to normal pressure.
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