Key result
Mild hypertension was associated with higher resting sympathetic drive and a blunted nocturnal reduction in the low-frequency spectral component of R-R interval variability compared to normotensives.
Why the study?
Does the circadian relationship between systemic arterial pressure and cardiac sympathetic drive differ in subjects with mild hypertension compared to normotensive subjects?
Population
29 subjects (18 with mild hypertension and 11 normotensive subjects)
Comparison
Simultaneous non-invasive intermittent arterial… vs Normotensive subjects
Design
Cross-sectional
Follow-up
24 h
Authors
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Should not yet change practice in mild hypertension; leaves open whether sympathetic circadian disruption drives risk or outcomes.
Observational (n=29)
Does the circadian relationship between systemic arterial pressure and cardiac sympathetic drive differ in subjects with mild hypertension compared to normotensive subjects?
Mild hypertension is associated with altered circadian dynamics of cardiac sympathetic drive, characterized by a lack of nocturnal reduction in sympathetic activity despite blood pressure dipping.
Guzzetti et al. (1994) conducted an observational in Mild hypertension (n=29). Mild hypertension vs. Normotensive subjects was evaluated on Normalized power of the low-frequency spectral component of R-R interval variability. Mild hypertension was associated with higher resting sympathetic drive and a blunted nocturnal reduction in the low-frequency spectral component of R-R interval variability compared to normotensives.
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