Key result
Saddle pulmonary embolism mimics STEMI with lateral ST elevation and complete heart block.
Why the study?
Pulmonary embolism can present with non-specific symptoms overlapping with acute coronary syndrome, and electrocardiogram findings of ST-segment elevations and complete heart block are extremely rare.
Case Report (n=1)
No
This case report highlights that massive saddle pulmonary embolism can rarely present with both ST-segment elevation and complete heart block mimicking acute coronary syndrome, necessitating a high index of suspicion for thromboembolic disease.
Answers are grounded in this paper and cite their sources.
Consider PE in ACS mimics with heart block despite non-obstructive coronaries; extends known ECG manifestations but leaves open broader applicability.
Pulmonary embolism can present with non-specific symptoms that overlap with acute coronary syndrome, such as chest pain, shortness of breath, and palpitations. Common electrocardiogram findings include sinus tachycardia and right bundle branch block; ST-segment elevations and complete heart block are extremely rare. We report a case of a 77-year-old man who initially presented with electrocardiogram findings of transient complete heart block and ST-segment elevation, which raised concern for acute coronary syndrome. Left heart catheterization was performed and did not reveal significant obstructive disease. Computed tomography pulmonary angiography with saddle pulmonary embolism suggested that thromboembolic disease was the main cause of the electrocardiogram changes. Clinicians should maintain a high index of suspicion for pulmonary embolism in patients presenting with abnormal electrocardiogram results and any underlying risk factors so as not to miss a life-threatening diagnosis.
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Nakapakorn et al. (2026) conducted a case report in Pulmonary embolism presenting with ST-segment elevation and complete heart block (n=1). Endovascular thrombectomy and veno-arterial extracorporeal membrane oxygenation (VA ECMO) was evaluated on In-hospital survival and neurological outcome. Saddle pulmonary embolism in a 77-year-old man presented with lateral ST-segment elevation, transient complete heart block, and peak troponin T of 3,060 ng/L despite non-obstructive coronary arteries.
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