Key result
Recent incident AF diagnosis is linked to ~59% lower ischemic stroke risk vs earlier decades.
Why the study?
Does contemporary management of atrial fibrillation (2010–2025 vs 1995–2010) reduce the long-term risk of ischaemic stroke and late-onset dementia in Danish patients with incident atrial fibrillation?
Cohort (n=489,705)
Yes
Does contemporary management of atrial fibrillation (2010–2025 vs 1995–2010) reduce the long-term risk of ischaemic stroke and late-onset dementia in Danish patients with incident atrial fibrillation?
Between 1995 and 2025, Danish patients with incident atrial fibrillation experienced a substantial 59% decline in ischaemic stroke risk alongside increased oral anticoagulation use, but a much smaller 23% decline in dementia risk, suggesting that stroke prevention alone may not fully mitigate AF-related cognitive decline.
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Charlotte Middelfart (2026) conducted a cohort in Incident atrial fibrillation (n=489,705). Diagnosis of atrial fibrillation in 2010–2025 vs. Diagnosis of atrial fibrillation in 1995–2010 was evaluated on Ischaemic stroke (HR 0.41, 95% CI 0.40-0.41). Incident AF diagnosis in 2010–2025 vs 1995–2010 was associated with a 59% lower hazard of ischaemic stroke (HR 0.41) and a 23% lower hazard of dementia (HR 0.77).
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