Why the study?
The association between the Chinese visceral adiposity index (CVAI) and lipid accumulation product (LAP) and hypertension in type 2 diabetes mellitus subjects warranted exploration.
Are the Chinese visceral adiposity index (CVAI) and lipid accumulation product (LAP) associated with hypertension in patients with type 2 diabetes mellitus?
Cross-Sectional (n=4,155)
No
Are the Chinese visceral adiposity index (CVAI) and lipid accumulation product (LAP) associated with hypertension in patients with type 2 diabetes mellitus?
In Chinese patients with type 2 diabetes, both the Chinese visceral adiposity index (CVAI) and lipid accumulation product (LAP) are independently associated with prevalent hypertension, with CVAI showing a linear dose-response relationship and LAP demonstrating a nonlinear threshold effect at 44.2.
Background The present study explored the association between the Chinese visceral adiposity index (CVAI) and lipid accumulation product (LAP) and hypertension in type 2 diabetes mellitus (T2DM) subjects. Methods A total of 4,155 T2DM individuals were enrolled from the Second Hospital of Shijiazhuang in this cross-sectional investigation. We employed multivariable logistic regression, restricted cubic spline (RCS) modeling, threshold effect assessment, and stratified subgroup analyses. Missing covariates were addressed through multiple imputation, while complete-case data were used for sensitivity evaluation. Results Among 4,155 participants (68.5% hypertensive), CVAI and LAP were positively associated with hypertension (P for trend < 0.001). Q4 vs. Q1 OR was 3.27 (95% CI: 2.66–4.02) for CVAI and 3.01 (95% CI: 2.43–3.72) for LAP. RCS evaluation demonstrated a significant nonlinear relationship between LAP and hypertension (P for non-linearity < 0.001), identifying a threshold value of 44.187 (95% CI: 42.141–46.233). CVAI showed linear associations in both sexes (P for non-linearity: 0.177 males, 0.055 females). Subgroup analyses showed consistent associations across strata (all P for interaction > 0.05). Conclusions CVAI and LAP are associated with hypertension in T2DM patients. LAP exhibits a nonlinear relationship with a threshold effect at approximately 44.2.
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Xing et al. (2026) conducted a cross-sectional in Type 2 diabetes mellitus (n=4,155). Chinese visceral adiposity index (CVAI) quartile 4 and lipid accumulation product (LAP) quartile 4 vs. Lowest quartile (Q1) of CVAI and LAP was evaluated on Prevalence of hypertension (OR 3.27, 95% CI 2.66-4.02, p=<0.001).
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