Key result
EVOQUE TTVR is linked to lower RV inflow contraction versus T-TEER despite preserved global function.
Why the study?
Although orthotopic transcatheter tricuspid valve replacement effectively reduces tricuspid regurgitation, the impact of its radial force-dependent anchoring mechanism on basal right ventricular contraction and reverse remodeling was unknown.
Does transcatheter tricuspid valve replacement (EVOQUE) alter regional right ventricular contraction patterns compared to transcatheter edge-to-edge repair (T-TEER) in patients with severe tricuspid regurgitation?
Observational (n=393)
Does transcatheter tricuspid valve replacement (EVOQUE) alter regional right ventricular contraction patterns compared to transcatheter edge-to-edge repair (T-TEER) in patients with severe tricuspid regurgitation?
Answers are grounded in this paper and cite their sources.
Transcatheter tricuspid valve replacement with EVOQUE causes sustained regional contraction impairment in the RV inflow segment due to radial force-dependent anchoring, yet preserves long-term recovery of global RV function.
Abstracts Background Orthotopic transcatheter tricuspid valve replacement (TTVR) provides effective reduction of tricuspid regurgitation (TR). However, the impact of the radial force-dependent anchoring mechanism (e.g. EVOQUE) on basal right ventricular (RV) contraction remains unknown. Aims We aimed to investigate changes in RV contraction patterns following EVOQUE compared with transcatheter edge-to-edge repair (T-TEER) to observe differences in segmental contraction and possible implications for right ventricular reverse remodeling. Methods and results We retrospectively analyzed 393 patients with severe TR undergoing tricuspid transcatheter intervention (EVOQUE, n=43; T-TEER, n=350). 3D-echocardiography was performed at baseline and serial follow-up to 2 years. RV contraction patterns were quantified using the ReVISION software, which allows analysis of 15 RV segments. Changes over the course of follow-up were assessed using paired analyses and linear mixed-effects models adjusted for covariates. At baseline, regional RV contraction patterns were comparable between treatment groups. Both interventions were associated with an immediate reduction in global RV function after the procedure. During follow-up, however, patients undergoing TTVR demonstrated persistent impairment of the right ventricular inflow segment, whereas all RV segments recovered following T-TEER. After multivariable adjustment, inflow segment contraction remained significantly lower after EVOQUE compared with T-TEER up to 2 years. Despite persistent regional impairment, global RV function recovered substantially after TTVR. Conclusion EVOQUE is associated with sustained impairment of contraction of the right ventricular inflow segment while preserving substantial long-term recovery of global RV function. These findings suggest that radial force-dependent valve anchoring alters regional RV mechanics without preventing overall right ventricular reverse remodeling.
No takes yet. Share an insight, caveat, or question.
Weckbach et al. (2026) conducted an observational in Severe tricuspid regurgitation (n=393). Orthotopic transcatheter tricuspid valve replacement (EVOQUE) vs. Transcatheter edge-to-edge repair (T-TEER) was evaluated on Regional right ventricular contraction patterns (15 RV segments via 3D-echocardiography) and global RV function. EVOQUE transcatheter tricuspid valve replacement (n=43) resulted in significantly lower RV inflow segment contraction up to 2 years versus T-TEER (n=350), though global RV function recovered.
Synapse has enriched 10 related papers. Consider them for comparative context: