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(1R,2S,5S)-2-Diphenyl-t-butylsiloxymethyl-3-oxabicyclo[3.3.0]octan-7-one (3), prepared from D-ribonolactone, has been converted in six steps into the biologically active prostacyclin analogue (15RS)-11-deoxy-11-oxacarbacyclin methyl ester (2; X = O).
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Mann et al. (1986) studied this question.
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