Key result
Ultrafast 3-minute GMPI matches standard 6-minute scans for quantitative perfusion and functional parameters.
Why the study?
The feasibility and minimum scan time of ultrafast gated myocardial perfusion imaging using a dedicated solid-state cardiac camera needed to be explored.
Does a 3-minute ultrafast gated myocardial perfusion imaging scan using a dedicated solid-state CZT cardiac camera maintain quantitative accuracy for perfusion and left ventricular function parameters compared to a standard 6-minute scan in patients with suspected coronary artery disease?
Cohort (n=76)
No
Does a 3-minute ultrafast gated myocardial perfusion imaging scan using a dedicated solid-state CZT cardiac camera maintain quantitative accuracy for perfusion and left ventricular function parameters compared to a standard 6-minute scan in patients with suspected coronary artery disease?
Answers are grounded in this paper and cite their sources.
An ultrafast 3-minute gated myocardial perfusion imaging protocol using a dedicated solid-state CZT camera maintains quantitative perfusion and functional accuracy comparable to a 6-minute scan in a Chinese cohort, though caution is warranted for functional quantification in males and patients with higher BMI.
Purpose To explore the feasibility of ultrafast gated myocardial perfusion imaging (GMPI) using a dedicated solid-state cardiac camera. Methods Seventy-six consecutive patients who were suspected with coronary artery disease referred for gated-MPI scan on the Discovery NM 530c (DNM) were retrospectively included. Thirty patients were selected as the test group to determine the minimum scan time and was validated in all the included patients. The original 6-min list-mode raw data from the test group were reframed into 1–5 min datasets, while the rest patients were reframed to generate the minimum scan time dataset. Subgroup analysis of stress and rest scan, male and female patients, different body mass index (BMI), perfusion defect severity were performed. All datasets were quantified using automated method including perfusion and functional parameters, additional visual score was performed by three clinicians. Quantitative parameters between different scan times were compared using Wilcoxon test or paired t test. The agreement of quantitative parameters between reframed scan and original 6-min scan was analyzed using intraclass correlation coefficient. Results The minimum scan time was determined as 3 min in the test group. No difference was observed between 3-min and 6-min scan (P > 0.05 for all parameters). For subgroup analysis, EDV (p = 0.04) and ESV (P < 0.001) in male patients, ESV (p = 0.001) and EF (P = 0.008) in patients with big BMI were found with significant differences, while other subgroups showed no significant differences (P > 0.05). Conclusion The DNM camera allows for a minimum of 3-min scan for GMPI without compromising quantitative accuracy of perfusion and function analysis.
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Zhao et al. (2026) conducted a cohort in Suspected coronary artery disease (n=76). Ultrafast 3-minute gated myocardial perfusion imaging (GMPI) scan on Discovery NM 530c vs. Original 6-minute list-mode GMPI scan on Discovery NM 530c was evaluated on Quantitative accuracy and agreement of perfusion and left ventricular functional parameters between 3-minute and 6-minute scans (p=>0.05). Ultrafast 3-min GMPI using the DNM camera showed no significant differences in quantitative perfusion and functional parameters compared to standard 6-min scans (P > 0.05).
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