Key result
Diabetes linked to ~2.4-fold higher hs-CRP levels without differences in cardiac biomarkers.
Why the study?
Diabetes mellitus is associated with increased cardiovascular morbidity, but the pattern of selected inflammatory and cardiac biomarkers among people with and without diabetes may vary across populations.
Does diabetes mellitus status associate with higher concentrations of biomarkers of systemic inflammation (hs-CRP), cardiac stress (NT-proBNP), and myocardial injury (troponin I, CK, CK-MB) in adult clinic attendees in Botswana?
Cross-Sectional (n=133)
Yes
Does diabetes mellitus status associate with higher concentrations of biomarkers of systemic inflammation (hs-CRP), cardiac stress (NT-proBNP), and myocardial injury (troponin I, CK, CK-MB) in adult clinic attendees in Botswana?
In adult clinic attendees in Botswana, diabetes mellitus is independently associated with significantly elevated systemic inflammation (hs-CRP) without significant baseline differences in cardiac injury or wall-stress biomarkers (troponin I, CK, CK-MB, NT-proBNP).
hs-CRP elevation in diabetes supports inflammation focus; leaves open prognostic value and clinical utility.
Background: Diabetes mellitus is associated with increased cardiovascular morbidity, but the pattern of selected inflammatory and cardiac biomarkers among people with and without diabetes may vary across populations. This study compared selected biomarkers between participants with and without diabetes mellitus. Methods: This cross-sectional comparative study included 133 clinic attendees in Gaborone, Botswana: 71 with diabetes and 62 without diabetes. Biomarkers measured were high-sensitivity C-reactive protein (hs-CRP), creatine kinase (CK), CK-MB, troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP). Continuous variables were summarised using medians and interquartile ranges (IQRs) and compared using Mann–Whitney U tests. Holm adjustment was applied across five biomarker comparisons. Adjusted associations were examined using separate log-linear regression models for each biomarker, controlling for age, sex, recalculated body mass index and systolic blood pressure. Background: Diabetes mellitus is associated with increased cardiovascular morbidity, but the pattern of selected inflammatory and cardiac biomarkers among people with and without diabetes may vary across populations. This study compared selected biomarkers between participants with and without diabetes mellitus. Methods: This cross-sectional comparative study included 133 clinic attendees in Gaborone, Botswana: 71 with diabetes and 62 without diabetes. Biomarkers measured were high-sensitivity C-reactive protein (hs-CRP), creatine kinase (CK), CK-MB, troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP). Continuous variables were summarised using medians and interquartile ranges (IQRs) and compared using Mann–Whitney U tests. Holm adjustment was applied across five biomarker comparisons. Adjusted associations were examined using separate log-linear regression models for each biomarker, controlling for age, sex, recalculated body mass index and systolic blood pressure.
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Musonda et al. (2026) conducted a cross-sectional in Diabetes mellitus (n=133). Diabetes mellitus vs. No diabetes mellitus was evaluated on High-sensitivity C-reactive protein (hs-CRP) concentration (alongside CK, CK-MB, troponin I, and NT-proBNP) (Adjusted geometric mean ratio 2.41, 95% CI 1.56-3.72, p=<0.001 (Holm-adjusted <0.001)). Diabetes mellitus was associated with 2.41-fold higher adjusted hs-CRP concentrations (95% CI 1.56-3.72; p<0.001), whereas CK, CK-MB, troponin I, and NT-proBNP did not differ significantly.
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