Key result
Brachiocephalic end-diastolic pulse wave velocity is uniquely associated with vascular cognitive impairment.
Why the study?
The respective roles of atherogenesis factors and arterial stiffness indicators in the development of vascular cognitive impairments in patients without extensive focal brain lesions required clarification.
Do atherogenesis factors and arterial stiffness indicators influence the development of vascular cognitive impairments in patients without extensive focal brain lesions?
Observational
Do atherogenesis factors and arterial stiffness indicators influence the development of vascular cognitive impairments in patients without extensive focal brain lesions?
Regional arterial stiffness measured by end diastole pulse wave velocity in the brachiocephalic arteries, rather than traditional atherogenesis markers or lipid profiles, significantly influences the development of vascular cognitive impairment in patients without extensive focal brain lesions.
Answers are grounded in this paper and cite their sources.
Arterial stiffness assessment should not yet change vascular cognitive impairment evaluation; leaves open validation in prospective cohorts.
This study analyzes the role of atherogenesis factors and ar terial stiffness indicators in the devel - opment of vascular cognitive impairments, including dementia and mild cognitive impairment, in patients without extensive focal brain lesions. The influence of atherogenesis indicators such as the percentage of maximal stenosis of brachiocephalic arteries, intima-media complex thickness in the same arteries, and blood lipid profiles (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, atherogenic index) was assessed. Ar teriosclerosis markers were represented by parameters of stiffness of central ar teries (carotid-femoral pulse wave velocit y, augmentation index) and regional (brachio -cephalic) arteries (pulsatility index and end diastole pulse wave velocit y). The study demonstrated that end diastole pulse wave velocit y is the only statistically significant factor influencing the formation of vascular cognitive impairment.
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Ivanova et al. (2025) conducted an observational in Vascular cognitive impairments (including dementia and mild cognitive impairment). Atherogenesis factors (brachiocephalic artery maximal stenosis, intima-media thickness, lipid profiles) and arteriosclerosis markers (central and regional arterial stiffness) was evaluated on Development of vascular cognitive impairment (including dementia and mild cognitive impairment). End diastole pulse wave velocity in brachiocephalic arteries was the only statistically significant factor influencing the formation of vascular cognitive impairment.
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