A Comparative Analysis of Mean Platelet Volume and Other Platelet Indices in Patient of Acute Myocardial Infarction with Healthy ControlProspective Study

Q: What are the key findings of this study?

Patients with acute myocardial infarction had significantly higher mean platelet volume compared to healthy controls (11.97±1.46 vs 10.72±0.94 fL, p<0.001).

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Acute myocardial infarction (n=120). Intervention: Acute myocardial infarction vs. Healthy age- and sex-matched controls. Primary outcome: Mean platelet volume (MPV, fL) (p=<0.001).

Q: What does this research mean for the field?

Patients with acute myocardial infarction have significantly higher mean platelet volume compared to healthy controls. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate mean platelet volume and other platelet indices in patients presenting with acute myocardial infarction compared with healthy controls.

Dr P. S Pipliwal

doi:10.18535/jmscr/v5i2.31

February 6, 2017Journal of Medical Science And clinical ResearchOpen Access

A Comparative Analysis of Mean Platelet Volume and Other Platelet Indices in Patient of Acute Myocardial Infarction with Healthy ControlProspective Study

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Key result

Acute myocardial infarction is linked to ~1.3-fL higher mean platelet volume versus healthy controls.

P<0.001
n=120

Why the study?

Platelets play an important role in atherosclerosis and thrombus formation, and mean platelet volume is affected by inflammation, but there is little data regarding its relation with coronary artery disease.

Key Points

To evaluate mean platelet volume and other platelet indices in patients presenting with acute myocardial infarction compared with healthy controls.
Comparative case-control study conducted at SMS Medical College, Rajasthan.
Included 60 patients with acute myocardial infarction diagnosed by symptoms, ECG changes, and troponin I/T, alongside 60 age- and sex-matched healthy controls.
Blood samples for mean platelet volume and related platelet indices were drawn within 6 hours of symptom onset prior to anticoagulant administration.
Patients with myocardial infarction had significantly higher mean platelet volume (11.97 ± 1.458 vs 10.72 ± 0.940 fl; p < 0.001) and platelet distribution width (15.23 vs 13.25 fl) compared to healthy controls.
Platelet large cell ratio was higher in cases (35.76% vs 31.40%; p < 0.0015), whereas platelet count (231.25 ± 67.27 vs 276.38 ± 120; p = 0.0135) and plateletcrit (0.266 ± 0.0641 vs 0.320 ± 0.0133; p < 0.0055) were lower.
Receiver operating characteristic analysis for mean platelet volume yielded an area under the curve of 0.762 (95% CI, 0.673–0.851; p = 0.000), with an optimal cutoff of 11.65 fl demonstrating 66.7% sensitivity and 53.33% specificity for predicting myocardial infarction.

Study Design

Type

Case-Control (n=120)

Multicenter

No

PICO

P

Population

120 participants (60 acute myocardial infarction patients within 6 hours of symptom onset before anticoagulation and 60 age- and sex-matched healthy controls; mean age 56.6 years, 26.7% female) evaluated in a hospital-based case-control study in India.

E

Exposure / Comparator

Acute myocardial infarction vs Healthy age- and sex-matched controls

O

Primary Outcome

Mean platelet volume (MPV, fL), p=<0.001

Main Result

Absolute Event Rate: 11.97% vs 10.72%

p-value: p=<0.001

Limitations

Difficulty determining whether the relationship between platelet size and cardiovascular risk is discrete or continuous using MPV
Variability in time between blood sample collection and measurement of MPV across studies
Lack of longitudinal patient follow-up due to the case-control study design
Difficulty standardizing blood collection, processing, and handling procedures for multicenter laboratory testing

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Implication

Comparative study shows elevated mean platelet volume in acute myocardial infarction patients, suggesting its potential value in cardiovascular risk assessment.

Abstract

Background: Coronary artery disease caused by atherosclerosis and its complications. Platelets has important role in atherosclerosis and thrombus formation. Mean platelet volume is affected by inflammation and there is little data regarding its relation with coronary artery disease.Aims & Objective: To study the mean platelet volume and other platelet indices in patient of acute myocardial infarction with healthy controls.Material and Methods: This study was a comparative analysis done in the department of medicine at SMS medical college Rajasthan.60 subjects with acute myocardial infarction diagnosed on the basis of symptoms, ECG changes and Troponin I/T was compared with 60 healthy individuals of same age and sex.MPV and other platelet indices done within 6 hours of symptoms before administration of anticoagulant.Inclusion and exclusion criteria was applied in both groups Results: It was observed that cases has lower platelet count, higher MPV higher PDW higher P-LCR, low PCT levels as compared to healthy controls Conclusion: Measurement of MPV may be of some benefit in detecting those patients at higher risk for CAD Keywords: Acute myocardial infarction, MPV, coronary artery disease.

Discussion

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Cite This Study

Dr P. S Pipliwal (2017) conducted a case-control in Acute myocardial infarction (n=120). Acute myocardial infarction vs. Healthy age- and sex-matched controls was evaluated on Mean platelet volume (MPV, fL) (p=<0.001). Patients with acute myocardial infarction had significantly higher mean platelet volume compared to healthy controls (11.97±1.46 vs 10.72±0.94 fL, p<0.001).

synapsesocial.com/papers/6ae8a0c2108c9024b029dfba https://doi.org/10.18535/jmscr/v5i2.31

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A Comparative Analysis of Mean Platelet Volume and Other Platelet Indices in Patient of Acute Myocardial Infarction with Healthy ControlProspective Study

Key Points

Study Design

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A Comparative Analysis of Mean Platelet Volume and Other Platelet Indices in Patient of Acute Myocardial Infarction with Healthy ControlProspective Study

Key Points

Study Design

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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