Key result
Mean platelet volume was significantly higher in patients with acute coronary syndrome compared to matched controls (9.722 vs 7.896; p<0.00001).
Why the study?
Platelets play a major role in ACS pathogenesis, and increased mean platelet volume is thought to be associated with myocardial damage.
Is mean platelet volume significantly elevated in patients with acute coronary syndrome compared to healthy controls?
Case-Control (n=100)
Is mean platelet volume significantly elevated in patients with acute coronary syndrome compared to healthy controls?
Absolute Event Rate: 9.722% vs 7.896%
p-value: p=<0.00001
Mean platelet volume is significantly elevated in patients with acute coronary syndrome and may serve as a cost-efficient early predictive marker in the emergency room.
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MPV may support early ACS risk stratification where biomarkers are unavailable; leaves open incremental prognostic value in prospective cohorts.
Bilagi et al. (2019) conducted a case-control in Acute coronary syndrome (n=100). Acute coronary syndrome vs. Controls with normal ECG and no history of ischemic heart disease was evaluated on mean platelet volume (p=<0.00001). Mean platelet volume was significantly higher in patients with acute coronary syndrome compared to matched controls (9.722 vs 7.896; p<0.00001).
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