Key result
Coronary microvascular dysfunction in INOCA is linked to early HFpEF on exercise hemodynamic testing.
Why the study?
While a high prevalence of coronary microvascular dysfunction (CMD) is established in patients with overt HFpEF, whether CMD among patients with ischemia and non-obstructive coronary arteries (INOCA) is a precursor to HFpEF remained unclear.
Is coronary microvascular dysfunction associated with early heart failure with preserved ejection fraction elicited by exercise hemodynamic testing in patients with INOCA?
Observational
Yes
Is coronary microvascular dysfunction associated with early heart failure with preserved ejection fraction elicited by exercise hemodynamic testing in patients with INOCA?
Answers are grounded in this paper and cite their sources.
This retrospective multicenter analysis evaluates whether coronary microvascular dysfunction in INOCA patients is associated with early HFpEF identified during exercise right heart catheterization.
Heart failure with preserved ejection fraction (HFpEF) represents a major diagnotic and therapeutic challenge. Overlapping clinical characteristics suggest there may be common pathophysiologic mechanisms that link the syndromes of coronary microvascular dysfunction (CMD) and HFpEF.1 While a high prevalence of CMD is established in patients with overt HFpEF,2 whether CMD among patients with ischemia and non-obstructive coronary arteries (INOCA) may be a precursor to HFpEF is not clear. To evaluate this possibility, we conducted a retrospective multicenter analysis of INOCA patients who underwent intracoronary physiology testing followed by exercise right heart catheterization.
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Park et al. (2026) conducted an observational in Ischemia and non-obstructive coronary arteries (INOCA). Coronary microvascular dysfunction (CMD) vs. No coronary microvascular dysfunction was evaluated on Early heart failure with preserved ejection fraction (HFpEF) elicited by exercise hemodynamic testing. Coronary microvascular dysfunction in INOCA patients is associated with early HFpEF elicited by exercise hemodynamic testing (quantitative results not reported in abstract).
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