Key result
Ross procedure in young children yields 100% event-free survival with zero operative mortality at 14 months.
Why the study?
The potential advantages of the Ross procedure in children under 10 years of age have yet to be validated, with remaining concerns regarding progressive dilatation of the pulmonary autograft and potential homograft stenosis.
Does aortic root replacement using the Ross procedure provide safe and satisfactory early outcomes without progressive autograft dilatation in children under 10 years of age?
Cohort (n=11)
Yes
Does aortic root replacement using the Ross procedure provide safe and satisfactory early outcomes without progressive autograft dilatation in children under 10 years of age?
This retrospective two-center study demonstrates that the Ross procedure can be safely performed in children under 10 years of age with 100% early event-free survival and no early progressive autograft dilatation.
Answers are grounded in this paper and cite their sources.
Experience with Ross procedure in young children remains limited; leaves open need for prospective validation of autograft durability.
BACKGROUND AND AIMS OF THE STUDY: The potential advantages of the Ross procedure in children under 10 years of age have yet to be validated. Concerns remain regarding progressive dilatation of the pulmonary autograft and potential homograft stenosis. We present our experience in this age population. METHODS: A retrospective analysis of aortic root replacement using the Ross procedure in 11 young children (nine males, two females; median age 84 months; range 3 months to 10 years) between January 1996 and January 1999 was performed jointly in two pediatric surgical centers. RESULTS: There were no operative deaths. Mean hospital stay was 12 +/- 4 days, and mean follow up 14.5 +/- 8 months. The event-free survival (death, reoperation, endocarditis, arrhythmia) was 100%. Currently, nine children are in NYHA functional class I, and two in class II. The autograft and homograft were evaluated by serial echocardiography. There was no sign of progressive dilatation of the autograft. Aortic regurgitation was trivial in four children and mild in seven. No growth of the autograft was noted; this was consistent with minimal somatic growth. Homograft peak gradients remained low during the follow up. CONCLUSIONS: Although the pulmonary autograft procedure is more complex than other types of aortic valve replacement, it can be safely applied in children. Early follow up indicates satisfactory performance of the autograft. If dilatation will not occur, pulmonary root autograft may be an attractive substitute for diseased aortic valves in children.
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Vitale et al. (1999) conducted a cohort in Diseased aortic valves requiring aortic root replacement (n=11). Ross procedure (aortic root replacement using pulmonary autograft) was evaluated on Event-free survival (death, reoperation, endocarditis, arrhythmia). The Ross procedure in children under 10 achieved 100% event-free survival and 0% operative mortality over a mean 14.5-month follow-up, with no progressive autograft dilatation.
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