Key result
Oral fat increases serum apo A-I and A-II levels, whereas intravenous fat causes scarcely any change.
Why the study?
The correlation between lipid metabolism and high density lipoprotein required elucidation by determining serum apolipoprotein A-I and A-II levels after oral and intravenous fat administration.
Answers are grounded in this paper and cite their sources.
Demonstrates oral fat ingestion transiently elevates serum apolipoproteins A-I and A-II whereas intravenous fat does not, indicating intestinal contribution to apolipoprotein production.
Serum apolipoprotein A-I and A-II levels were determined after oral and intravenous fat administration to elucidate the correlation between lipid metabolism and high density lipoprotein. For oral fat administration, four normal adult males ingested 55g of butter after an overnight fast. For intravenous fat administration, five normal adult males and eleven patients with liver disease were injected 1ml of 10% fat emulsion (Intralipid) per kg of body weight after an overnight fast. The A-I and A-II measurement was carried out by the rocket immunoelectrophoresis. Serial blood specimens were taken and measured for their concentration of A-I, A-II and triglyceride.Serum apo A-I and A-II levels scarcely varied after intravenous fat administration, but in some cases decreased slightly. On the other hand, the apoprotein levels increased after oral fat administration and peaked after 60 minutes. Serum apo A-I and A-II levels varied concomitantly, therefore, the ratio of apo A-I/apo A-II remained constant. These results suggested that serum apolipoprotein A-I and A-II levels were influenced partially by their synthesis in the small intestine.
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FUJII et al. (1980) studied Lipid metabolism in healthy adults and liver disease patients (n=20). Oral fat administration (butter) and intravenous fat administration (10% Intralipid) vs. Intravenous fat administration vs oral fat administration; liver disease patients vs normal controls was evaluated on Changes in serum apolipoprotein A-I and A-II concentrations. Oral fat administration of 55 g butter increased serum apo A-I and A-II levels peaking at 60 minutes, whereas intravenous Intralipid (1 ml/kg) caused scarcely any change over 40 minutes.
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