Key result
Type IV hyperlipidemia links to reduced apolipoproteins A-I and A-II, mirroring lower HDL-cholesterol levels.
Cross-Sectional (n=64)
No
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Demonstrates distinct apolipoprotein A-I and A-II levels across hyperlipidemia types and strong links to HDL cholesterol, highlighting their role in lipid classification.
The concentrations of serum apolipoproteins A-I and A-II were determined in 64 hyperlipidemic subjects by the method of SRID and rocket immunoelectrophoresis. Further determinations were carried out on the levels of apoprotein B (rocket technique), the concentration of triglycerides, total cholesterol and HDL cholesterol.The concentrations of apo A-I and A-II in the type IV cases were lower than in type II subjects. The A-I and A-II levels were significantly correlated with the levels of HDL cholesterol but not with the levels of triglycerides or total cholesterol.The concentrations of apo B in the hyperlipidemic subjects were increased markedly and correlated with the levels of total cholesterol but not with the levels of triglycerides.The concentrations of apo A-I in hyperlipidemic subjects determined by SRID method were correlated with the values obtained by the rocket technique (r=+0.76, n=63), and indicated the validity of the method.
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SHONO et al. (1982) conducted a cross-sectional in Hyperlipidemia (n=64). Serum apolipoprotein A-I and A-II measurement by single radial immunodiffusion (SRID) across hyperlipidemia WHO types vs. Rocket immunoelectrophoresis and across WHO hyperlipidemia types (Type IV vs Type II) was evaluated on Correlation of serum apolipoprotein A-I between SRID and rocket immunoelectrophoresis, and apo A-I/A-II concentrations across hyperlipidemia types (r=+0.76, p=<0.001). Serum apolipoprotein A-I and A-II levels were lower in Type IV hyperlipidemia (113±32 and 25±8 mg/dl) and correlated significantly with HDL-cholesterol, while SRID and rocket methods correlated well (r=+0.76, p<0.001).
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