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BACKGROUND: Ewing sarcoma (ES) is an aggressive cancer in which the histologic response to neoadjuvant chemotherapy is a key prognostic factor. This study investigated the correlation between weight loss and chemotherapy response in 57 pediatric patients with ES. OBSERVATION: A significant, direct correlation (P=0.008) was found between weight loss and a good chemotherapy response: 93% of patients with ≥3% weight loss had a good response, compared with only 40% of those without. CONCLUSION: This may suggest that caloric restriction mimics the effects observed in other cancers, potentially reducing tumor proliferation and angiogenesis.
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Peled et al. (2026) studied this question.
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