Key result
PTP-1B AA genotype linked to ~9.6-fold higher risk of essential hypertension versus TT.
Why the study?
Multiple SNPs of the protein tyrosine phosphatase-1B (PTP-1B) gene have been associated with insulin-resistance conditions, prompting investigation into the role of PTP-1B gene polymorphism in essential hypertension and dyslipidemia.
Case-Control (n=57)
Answers are grounded in this paper and cite their sources.
PTP-1B polymorphism role in hypertension and dyslipidemia remains hypothesis-generating; larger prospective studies needed before any clinical consideration.
ObjectivesThe aim of the study was to investigate the role of protein tyrosine phosphatase-1B (PTP-1B) gene polymorphism in essential hypertension and dyslipidemia.BackgroundEssential hypertension is the most common chronic disease and an important risk factor for major health problems. PTP-1B has been recognized as a key modulator of several important physiological pathways. Multiple SNPs of PTP-1B have been shown to be associated with diseases accompanying insulin resistance, such as dyslipidemia and hypertension.Participants and methodsThe study included 57 individuals divided into two groups: group I comprised 37 hypertensive patients and group II comprised 20 healthy individuals as controls. The participants were subjected to the following: history taking and clinical examination, assessment of weight, height, and BMI, fasting blood sugar, lipid profile, renal function tests, and PCR-RFLP for determination of genotype and allele frequencies of the g54281T > A polymorphism of the PTP-1B gene.ResultsGroup I had statistically higher fasting blood sugar, weight, BMI, and TG. The TT genotype recorded higher frequency in group II than in group I (70%, 43.2%, respectively). While, AA genotype showed higher frequency in group I than in group II (29.7%, 5%, respectively) and TA genotype was higher in group I than in group II (27%, 25%, respectively). However, the differences were without statistical significance. The T allele was more prevalent in group II (82.5%) than in group I (56.8) and the A allele was more prevalent in group I (43.2%) than in group II (17.5%). TA carried a 1.75-fold higher risk than TT [confidence interval (CI): 0.48-6.36], whereas AA carried a 9.63-fold higher risk than TT (CI: 1.10-84.23). The A allele carried a 3.59-fold higher risk than the T allele (CI: 1.41-9.16). In group I, AA genotype was higher in BMI than TT, also TA and AA genotypes were higher in TG than TT.ConclusionThe g54281T > A polymorphism of the PTP-1B gene can be implicated in the pathogenesis of essential hypertension.
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El-khair et al. (2016) conducted a case-control in Essential hypertension and dyslipidemia (n=57). PTP-1B g54281T>A gene polymorphism (A allele / AA genotype) vs. T allele / TT genotype (and healthy controls) was evaluated on Essential hypertension (association with PTP-1B g54281T>A AA genotype vs TT genotype) (OR 9.63, 95% CI 1.10-84.23). The PTP-1B g54281T>A AA genotype carried a 9.63-fold higher risk of essential hypertension than TT (CI: 1.10-84.23), and the A allele carried a 3.59-fold higher risk than T (CI: 1.41-9.16).
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