Key result
Male TT homozygotes of the Gβ3 C825T polymorphism had a greater risk of obesity (RR 1.90, P=0.005), higher blood pressure, and more insulin resistance compared with C allele carriers.
Why the study?
Is the Gβ3 C825T polymorphism associated with increased blood pressure, obesity, and insulin resistance in a Caucasian population?
Population
1,512 Caucasian adults (737 men, 775 women) from a Belgian population study
Comparison
Presence of the T allele or TT genotype of the… vs C allele carriers
Design
Cross-sectional
Authors
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Supports Gβ3 C825T TT link to obesity and metabolic traits in Caucasian males; hypothesis-generating, should not yet change practice.
Cross-Sectional (n=1,512)
Is the Gβ3 C825T polymorphism associated with increased blood pressure, obesity, and insulin resistance in a Caucasian population?
Effect estimate: RR 1.90
p-value: p=0.005
Brand et al. (2003) conducted a cross-sectional in Obesity and hypertension (n=1,512). Gβ3 C825T polymorphism (TT genotype) vs. C allele carriers was evaluated on Risk of obesity in men (RR 1.90, p=0.005). Male TT homozygotes of the Gβ3 C825T polymorphism had a greater risk of obesity (RR 1.90, P=0.005), higher blood pressure, and more insulin resistance compared with C allele carriers.
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