Why the study?
Is the 825T allele of the G protein beta3 subunit associated with higher BMI and obesity in hypertensive individuals?
Population
197 hypertensive individuals recruited from the general population in the Heidelberg area.
Comparison
Presence of the 825T allele of the G protein… vs Absence of the 825T allele (CC genotype)
Design
Cross-sectional
Authors
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Should not change hypertension management; leaves open a genetic obesity link needing prospective confirmation.
Is the 825T allele of the G protein beta3 subunit associated with higher BMI and obesity in hypertensive individuals?
The 825T allele of the G protein beta3 subunit is associated with increased BMI and obesity in hypertensive individuals, suggesting a genetic link between enhanced G protein reactivity and weight gain.
Siffert et al. (1999) studied this question.
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