A comparison of KONAR and Amplatzer: are the p-values and reports of reintervention consistent?

Q: What are the key findings of this study?

KONAR-MFO versus ADO-I complication rates in VSD closure lacked statistical significance upon recalculation for complete heart block (0/28 vs 2/29, p=0.491) and mild aortic insufficiency (3/28 vs 0/29, p=0.112).

Q: What is the clinical evidence from this study?

Study design: Letter. Population: Patent arterial ducts and ventricular septal defects. Intervention: KONAR-multifunctional occluder (KONAR-MFO) vs. Amplatzer occluders (ADO-I).

Alper Akın

doi:10.1186/s43044-026-00790-z

October 30, 2026The Egyptian Heart JournalOpen Access

A comparison of KONAR and Amplatzer: are the p-values and reports of reintervention consistent?

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Key result

KONAR-MFO shows no significant difference in complication rates compared to ADO-I for VSD closure.

p=0.491
p=0.112

PICO

P

Population

Patients undergoing transcatheter closure of patent arterial ducts or ventricular septal defects with KONAR-MFO or Amplatzer devices, including a subgroup of 57 patients with ventricular septal defects.

I

Intervention / Comparator

KONAR-multifunctional occluder (KONAR-MFO) vs Amplatzer occluders (ADO-I)

Limitations

Small number of events and contingency table cells containing zeros
Inconsistencies between reported p-values (0.026 and <0.001) and recalculated Fisher's exact test p-values (0.491 and 0.112) in the original study
Discrepancies between tables (0%) and discussion text (5 patients, 2.9%) regarding re-intervention rates in the original study

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Cite This Study

Alper Akın (2026) conducted a letter in Patent arterial ducts and ventricular septal defects. KONAR-multifunctional occluder (KONAR-MFO) vs. Amplatzer occluders (ADO-I) was evaluated. KONAR-MFO versus ADO-I complication rates in VSD closure lacked statistical significance upon recalculation for complete heart block (0/28 vs 2/29, p=0.491) and mild aortic insufficiency (3/28 vs 0/29, p=0.112).

synapsesocial.com/papers/6aee6c1171a7594806220d07 https://doi.org/10.1186/s43044-026-00790-z

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A comparison of KONAR and Amplatzer: are the p-values and reports of reintervention consistent?

PICO

Limitations

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Discussion

Cite This Study

A comparison of KONAR and Amplatzer: are the p-values and reports of reintervention consistent?

PICO

Limitations

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Abstract

Discussion

Cite This Study

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