Why the study?
Does switching antihypertensive therapy to bedtime dosing reduce clinic blood pressure at 2 months compared to continuing morning dosing in nondipper hypertensive patients with uncontrolled clinic blood pressure?
Does switching antihypertensive therapy to bedtime dosing reduce clinic blood pressure at 2 months compared to continuing morning dosing in nondipper hypertensive patients with uncontrolled clinic blood pressure?
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This editorial commentary highlights a post hoc secondary RCT analysis showing that bedtime antihypertensive dosing substantially lowers 2-month clinic blood pressure and improves control rates compared to morning dosing in nondipper hypertensive patients.
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Pierdomenico et al. (2026) conducted an editorial in Hypertension with uncontrolled clinic blood pressure and nighttime nondipper pattern (n=60). Bedtime antihypertensive dosing (single or combined therapy, primarily long-acting calcium-channel blocker or angiotensin-converting enzyme inhibitor) vs. Morning (on awakening) antihypertensive dosing was evaluated on Baseline-adjusted clinic systolic blood pressure at 2 months (mm Hg) (MD -18 mmHg, 95% CI -22.4 to -13.8, p=<0.001).
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