Key result
Coronary heart disease is linked to ~1.9-fold higher serum small dense LDL levels.
Why the study?
The study aimed to compare serum small dense low-density lipoprotein cholesterol levels as a novel biomarker between coronary heart disease patients and healthy controls.
Cross-Sectional (n=220)
Yes
Answers are grounded in this paper and cite their sources.
Small dense LDL elevation warrants no practice change in CHD; hypothesis-generating and requires prospective validation for risk stratification.
Objective: To compare serum small dense low-density lipoprotein cholesterol levels in coronary heart disease (CHD) patients and healthy controls. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, in collaboration with AFIC Rawalpindi from Feb to Dec 2021. Methodology: A total of 220 participants were selected for the study, 120 healthy controls and 100 CHD patients. Fasting blood samples after 12 hours of fast were collected for lipid profile and small dense low-density lipoprotein cholesterol (sdLDL-C) levels. SdLDL-C levels were analyzed by automated, standardized enzymatic assay on Siemens Advia 1800 automated chemistry analyzer using Ex Denka Seiken kits. Results: Among the total participants, 154 (70%) were males, and 66(30%) were females. The median age of all participants was 55(IQR: 52 -56) years, while their median sdLDL-C was 0.93 (IQR: 0.56-1.08) mmol/L. Results showed that small, dense LDL cholesterol serum levels were significantly raised in CHD patients compared to healthy controls (p-value <0.05). Conclusion: The current study showed that patients with CHD had elevated small, dense LDL-C levels compared to the healthy control group.
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Saleem et al. (2022) conducted a cross-sectional in Coronary heart disease (n=220). Coronary heart disease vs. Healthy controls was evaluated on Serum small dense low-density lipoprotein cholesterol (sdLDL-C) concentration (mmol/L) (p=<0.001). Serum small dense LDL cholesterol levels were significantly elevated in coronary heart disease patients compared to healthy controls (median 1.08 vs 0.58 mmol/L, p<0.001).
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