Key result
Newly diagnosed hypertension is linked to prolonged LV dyssynchrony, predicting impaired systolic function.
Why the study?
Left ventricular systolic synchrony is known to be impaired in hypertension, but its impact on LV function in newly diagnosed hypertensive patients was unclear.
Observational (n=81)
Answers are grounded in this paper and cite their sources.
Dyssynchrony may aid systolic function assessment in new hypertension; leaves open its prognostic value and therapeutic role.
OBJECTIVES: Left ventricular (LV) systolic synchrony, defined as simultaneous peak contractions of corresponding cardiac segments, is well documented to be impaired in hypertension but its effect on LV function is not clear. The aim of this study was to assess the impacts of LV systolic dyssynchrony on LV function in newly diagnosed hypertensives. METHODS: Forty-eight newly diagnosed hypertensive patients and 33 controls were enrolled. All study population underwent a comprehensive echocardiographic evaluation including tissue synchrony imaging. The time to regional peak systolic tissue velocity (Ts) in LV by 12 segmental models was measured and two parameters of systolic dyssynchrony were computed. RESULTS: Baseline demographic characteristics were similar in both study groups. Dyssynchrony parameters prolonged in newly diagnosed hypertensive patients compared to controls: the standard deviation (SD) of 12 LV segments Ts (40.2 ± 21 vs. 26.2 ± 13.4, P = 0.003); the maximal difference in Ts between any 2 of 12 LV segments (123.3 ± 61.5 vs. 79.8 ± 37.9, P = 0.001). In multivariable analysis, Ts-SD-12 was found to be an independent predictor for systolic function (β=-0.29, P = 0.008). But, both diastolic and global functions were not independently related to Ts-SD-12. CONCLUSION: LV synchronization is impaired in newly diagnosed hypertensive patients. LV dyssynchrony is one of the independent predictors of systolic function in hypertensive patients.
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Kırış et al. (2012) conducted an observational in Newly diagnosed hypertension (n=81). Newly diagnosed hypertension (LV systolic dyssynchrony) vs. Healthy controls was evaluated on Standard deviation of time to regional peak systolic tissue velocity across 12 LV segments (Ts-SD-12) and its association with LV systolic function (β -0.29, p=0.003). Newly diagnosed hypertension was associated with prolonged LV systolic dyssynchrony (Ts-SD-12: 40.2 vs 26.2, P=0.003), which independently predicted LV systolic function (β=-0.29, P=0.008).
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