Characteristics of prediabetes, newly detected type 2 diabetes mellitus and associated factors among outpatients at Hanoi Heart Hospital

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Cardiovascular outpatients with prediabetes or newly detected type 2 diabetes mellitus (n=92). Intervention: eGFR =60 mL/min/1.73 m2. Primary outcome: Newly detected type 2 diabetes mellitus (versus prediabetes) (aOR 0.20, 95% CI 0.05-0.84, p=0.029).

Q: What does this research mean for the field?

Among cardiovascular outpatients with dysglycemia, an eGFR <60 mL/min/1.73 m² and calcium channel blocker use for less than one year are inversely associated with newly detected type 2 diabetes versus prediabetes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Q: What question did this study set out to answer?

To describe the characteristics of patients with prediabetes and newly detected type 2 diabetes, and to identify factors associated with newly detected diabetes versus prediabetes among cardiovascular outpatients.

Quynh Nga Vu; Trần Thanh Hoa

doi:10.47972/vjcts.vi.1944

November 9, 2026Tạp chí Phẫu thuật và Tim mạch và Lồng ngực Việt NamOpen Access

Characteristics of prediabetes, newly detected type 2 diabetes mellitus and associated factors among outpatients at Hanoi Heart Hospital

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Key result

eGFR <60 is linked to ~80% lower odds of newly detected type 2 diabetes.

aOR 0.20
95% CI 0.05-0.84
P=0.029
n=92

Why the study?

The characteristics and associated factors differentiating newly detected type 2 diabetes mellitus from prediabetes among cardiovascular outpatients at Hanoi Heart Hospital needed to be described and identified.

What clinical, laboratory, and medication factors are associated with newly detected type 2 diabetes mellitus compared with prediabetes among cardiovascular outpatients?

Key Points

To describe the characteristics of patients with prediabetes and newly detected type 2 diabetes, and to identify factors associated with newly detected diabetes versus prediabetes among cardiovascular outpatients.
Conducted a cross-sectional analytical study of 92 cardiovascular outpatients with prediabetes or newly detected type 2 diabetes at Hanoi Heart Hospital from May 2025 to July 2026.
Classified dysglycemia using fasting plasma glucose, HbA1c, or random glucose per modified ADA 2026 criteria without oral glucose tolerance testing.
Assessed factors associated with newly detected type 2 diabetes versus prediabetes using univariable and multivariable logistic regression.
Among 92 patients, 35 (38.0%) had prediabetes and 57 (62.0%) had newly detected type 2 diabetes, with a overall mean age of 63.97 ± 11.78 years and 62.0% male predominance.
In multivariable analysis (n=88), an eGFR <60 mL/min/1.73 m² (aOR=0.20; 95% CI: 0.05–0.84) and calcium channel blocker use for under one year (aOR=0.07; 95% CI: 0.01–0.71) were inversely associated with newly detected diabetes.
Low HDL-C (<0.9 mmol/L) showed a positive but non-significant trend with newly detected diabetes (aOR=7.80; 95% CI: 0.86–70.69; p=0.068), while HbA1c and random glucose levels were significantly elevated.

Study Design

Type

Cross-Sectional (n=92)

Multicenter

No

Structured PICO

What clinical, laboratory, and medication factors are associated with newly detected type 2 diabetes mellitus compared with prediabetes among cardiovascular outpatients?

P

Population

92 cardiovascular outpatients (mean age 63.97 years, 38.0% female) with prediabetes (38.0%) or newly detected type 2 diabetes (62.0%) evaluated in a cross-sectional study at Hanoi Heart Hospital.

E

Exposure

Clinical, metabolic, and treatment exposures evaluated for association with newly detected type 2 diabetes, specifically eGFR <60 mL/min/1.73 m², calcium channel blocker (CCB) use <1 year, and HDL-C <0.9 mmol/L

C

Comparator

Reference exposure categories (eGFR ≥60 mL/min/1.73 m², no current/discontinued CCB use, HDL-C ≥0.9 mmol/L) comparing newly detected type 2 diabetes against prediabetes

O

Outcome

Classification as newly detected type 2 diabetes mellitus versus prediabetes in multivariable logistic regression (n=88)surrogate

Main Result

Odds Ratio: 0.2 (95% CI 0.05–0.84)

Absolute Event Rate: 35.7% vs 66.2%

p-value: p=0.029

Limitations

Cross-sectional design precludes establishing causality
Convenience sampling at a single specialized cardiovascular hospital only among patients with dysglycemia limits generalizability
Oral glucose tolerance test (OGTT) was not performed, risking misclassification of isolated impaired glucose tolerance or post-challenge diabetes
Small sample size (n=92; n=88 in multivariable model with ~5 events per variable) and small exposure subgroups (only 7 patients using CCB <1 year) lead to unstable estimates and risk of overfitting
Missing laboratory data for 4 patients (HDL-C, creatinine/eGFR, CCB duration) and 6 patients (random glucose) handled by complete-case analysis
Cross-sectional design does not allow determination of causal relationships
Convenience sampling at a single specialty heart hospital restricted to patients already identified with dysglycemia limits generalizability
Lack of oral glucose tolerance test (OGTT) may miss isolated impaired glucose tolerance and cause misclassification between groups
Small sample size (~5 cases per variable in the main model) and very small exposure subgroups (only 7 patients on CCB <1 year) cause unstable regression estimates and risk of overfitting
Missing laboratory data for some variables analyzed via complete-case analysis (n=88 for main multivariable model, n=82 for extended model)

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

This study highlights the high burden of cardiovascular comorbidities among outpatients with newly detected dysglycemia and supports systematic glucose and HbA1c screening in high-risk cardiovascular outpatients, particularly those with low HDL-C.

Abstract

Objective: To describe the characteristics of patients with prediabetes and newly detected type 2 diabetes mellitus, and to identify factors associated with newly detected type 2 diabetes (versus prediabetes) among outpatients at Hanoi Heart Hospital. Methods: A cross-sectional study with an analytical component was conducted among 92 cardiovascular outpatients with prediabetes or newly detected type 2 diabetes at Hanoi Heart Hospital from May 2025 to July 2026. Associated factors were examined using univariable and multivariable logistic regression. Results: Thirty-five patients (38.0%) had prediabetes and 57 (62.0%) had newly detected type 2 diabetes. The mean age was 63.97 ± 11.78 years, and 62.0% were male. HbA1c and random glucose levels were significantly higher in patients with newly detected diabetes. In the multivariable model (n=88), eGFR <60 mL/min/1.73 m² (aOR=0.20; 95% CI: 0.05–0.84) and calcium channel blocker (CCB) use for less than one year (aOR=0.07; 95% CI: 0.01–0.71; only 7 patients) were inversely associated with newly detected diabetes. HDL-C <0.9 mmol/L showed a positive but non-significant trend (aOR=7.80; 95% CI: 0.86–70.69; p=0.068). Conclusion: Among cardiovascular outpatients with dysglycemia, low HDL-C (as a trend), eGFR <60 mL/min/1.73 m² and CCB use for less than one year were associated with newly detected type 2 diabetes. These associations do not establish causality and should be confirmed in larger longitudinal studies. The findings support systematic glucose/HbA1c screening in at-risk cardiovascular patients.

Discussion

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Cite This Study

Vu et al. (2026) conducted a cross-sectional in Cardiovascular outpatients with prediabetes or newly detected type 2 diabetes mellitus (n=92). eGFR <60 mL/min/1.73 m2 vs. eGFR >=60 mL/min/1.73 m2 was evaluated on Newly detected type 2 diabetes mellitus (versus prediabetes) (aOR 0.20, 95% CI 0.05-0.84, p=0.029). Among cardiovascular outpatients with dysglycemia, eGFR <60 mL/min/1.73 m2 (aOR 0.20) and CCB use <1 year (aOR 0.07) were inversely associated with newly detected type 2 diabetes versus prediabetes.

synapsesocial.com/papers/6af2b3898aac795b523cc7ec https://doi.org/10.47972/vjcts.vi.1944

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Characteristics of prediabetes, newly detected type 2 diabetes mellitus and associated factors among outpatients at Hanoi Heart Hospital

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Characteristics of prediabetes, newly detected type 2 diabetes mellitus and associated factors among outpatients at Hanoi Heart Hospital

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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