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The article presents a clinical case of hemochromatosis diagnosis with the presence of a heterozygous HFE His63Asp (H63D) mutation in a patient with liver damage. In our opinion, the reason leading to secondary iron retention in this case was the long-term intake of allopurinol. Correction of urate-lowering therapy led to a decrease in ferritin levels and normalization of liver parameters.
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Markova et al. (2026) studied this question.
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