Key result
Percutaneous LAAO shows promise for stroke prevention in AF, though definitive evidence remains lacking.
Why the study?
Percutaneous left atrial appendage occlusion has emerged as a potential nonpharmacologic approach to prevent stroke and systemic embolism in patients with atrial fibrillation, but the evidence underpinning this invasive technology is not definitive.
Does percutaneous left atrial appendage occlusion prevent stroke and systemic embolism in patients with atrial fibrillation?
Does percutaneous left atrial appendage occlusion prevent stroke and systemic embolism in patients with atrial fibrillation?
This review highlights the clinical tradeoffs and non-definitive nature of the trial evidence supporting percutaneous left atrial appendage occlusion for stroke prevention in atrial fibrillation.
Answers are grounded in this paper and cite their sources.
Nondefinitive evidence for LAA occlusion warrants clinical caution; leaves open its role versus anticoagulation in AF.
PURPOSE OF REVIEW: To allow readers to fully appreciate the uncertainties with this novel yet invasive approach to stroke prevention. RECENT FINDINGS: Percutaneous left atrial (LA) appendage occlusion has emerged as potential nonpharmacologic means to prevent stroke and systemic embolism in patients with atrial fibrillation. Yet the evidence underpinning this new technology is not definitive. SUMMARY: In this review, we consider the internal and external validity of the regulatory trials, pathophysiologic basis for LA appendage occlusion and clinical tradeoffs of the procedure.
No takes yet. Share an insight, caveat, or question.
Mandrola et al. (2019) conducted a review in Atrial fibrillation. Percutaneous left atrial appendage occlusion was evaluated on Stroke and systemic embolism. Percutaneous left atrial appendage occlusion has emerged as a potential nonpharmacologic means to prevent stroke and systemic embolism in atrial fibrillation, though evidence is not definitive.
Synapse has enriched 10 related papers. Consider them for comparative context: