Key result
Irbesartan lowers blood pressure and improves sexual function in hypertensive men with erectile dysfunction.
Why the study?
Erectile dysfunction is particularly common in patients with arterial hypertension due to shared vascular mechanisms, requiring antihypertensive pharmacotherapy that stabilizes blood pressure while managing sexual function. This review sought to analyze the therapeutic efficacy, hemodynamic effects, and pleiotropic effects of irbesartan in comorbid patients with arterial hypertension and erectile dysfunction.
Does irbesartan improve blood pressure control, endothelial function of the cavernous bodies, sexual function, and quality of life in comorbid patients with arterial hypertension and erectile dysfunction?
Does irbesartan improve blood pressure control, endothelial function of the cavernous bodies, sexual function, and quality of life in comorbid patients with arterial hypertension and erectile dysfunction?
This literature review evaluates the evidence from clinical studies regarding the efficacy of irbesartan in controlling blood pressure and improving sexual function and quality of life in patients with comorbid arterial hypertension and erectile dysfunction.
Answers are grounded in this paper and cite their sources.
May support irbesartan in hypertension with ED; hypothesis-generating and requires RCTs before practice change.
Arterial hypertension (AH) remains one of the most challenging global medical and social issues affecting more than a billion adults worldwide. Chronic high blood pressure provokes progressive damage to the vascular bed which naturally increases a risk of cardiovascular, cerebrovascular and renal complications. Along with this, erectile dysfunction (ED) is considered as a serious condition that significantly worsens psychoemotional state and overall quality of life of patients in modern medical practice. Over the past three decades, study data prove conclusively that ED is mainly based on vascular mechanisms. That's why, its incidence is especially high in persons with cardiovascular diseases or their risk factors. ED is particularly common in hypertensive patients. Efficient antihypertensive pharmacotherapy dedicated to blood pressure stabilization and ED management improves prognosis and quality of life in comorbid patients and increases their adherence to therapy. Antihypertensive drugs (i. e., blockers of the reninangiotensinaldosterone system) demonstrate clinically proved efficacy in patients with hypertension and ED. The therapy reliably reduces blood pressure (BP), provides effective daily BP control and improves sexual function indicators significantly. In this literature review, data collection and search methodology was developed to ensure representativeness and validity of an analysis of therapeutic efficacy of irbesartan in comorbid patients with AH and ED. Information search was carried out in leading repositories of peer reviewed medical literature (Scopus, Web of Science, PubMed/MEDLINE and eLIBRARY.RU). It included randomized controlled trials, prospective and cohort studies of both hemodynamic effects of irbesartan and its specific pleiotropic effect on the endothelial function of the cavernous bodies, and patients' quality of life. KEYWORDS: arterial hypertension, erectile dysfunction, endothelial dysfunction, oxidative stress, inflammation, blockers of the renin angiotensinaldosterone system, irbesartan. FOR CITATION: Ostroumova O.D., Ebzeeva E.Yu., Kochetkov A.I. Irbesartan, angiotensin II receptor blocker: antihypertensive therapy in comor- bid patients with erectile dysfunction. Russian Medical Inquiry. 2026;10(9):608–613 (in Russ.). DOI: 10.32364/2587-6821-2026-10-9-3
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Ostroumova et al. (2026) conducted a review in Arterial hypertension with comorbid erectile dysfunction. Irbesartan was evaluated on Hemodynamic effects (blood pressure control), endothelial function of the cavernous bodies, sexual function indicators, and quality of life. Irbesartan reliably reduces blood pressure, improves cavernous endothelial and sexual function, and enhances quality of life in hypertensive patients with erectile dysfunction (no quantitative data).
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