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A 39-year-old man suffering from Graves’ ophthalmopathy, which was resistant to steroids (with a clinical activity score of 5/7 and a moderate-severe EUGOGO grade), had a 68Ga-FAPI-46 PET/CT scan. This scan showed strong bilateral FAPI activity in the extraocular muscles, especially in the inferior recti, even though his visual acuity remained normal. A later low-dose 177Lu-FAPI-2286 retention study confirmed that the radiotracer stayed selectively within the recti. This example suggests that fibroblast activation protein-targeted theranostics could be a new way to image and possibly treat Graves’ orbitopathy.
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Umar et al. (2026) studied this question.
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