Key result
Fifty-one plant-derived antioxidants show preclinical cardioprotection against MI by mitigating oxidative stress and ferroptosis.
This comprehensive review highlights the cardioprotective roles, mechanistic insights, and structure-activity relationships of 51 plant-derived antioxidant compounds in managing oxidative stress-associated myocardial infarction.
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Plant-derived antioxidants merit clinical investigation in MI but should not alter practice; extends preclinical structure-activity insights for future trials.
Among cardiovascular diseases, myocardial infarction (MI) has become one of the leading causes of mortality worldwide, and the prevalence is anticipated to rise considerably in the coming years. Within non-surgical procedures, chemical drugs, including diuretics, vasodilators, calcium channel blockers, ꞵ blockers, angiotensin converting enzyme inhibitors, are now a well-established option to treat MI progression. However, these drugs are not developed to mitigate oxidative stress directly, which has been recently proven to contribute to MI advancement. Naturally occurring antioxidant compounds possess promising cardioprotective properties and have the potential to be used both as lead compounds for finding novel drugs and complementary therapy to manage MI. While some of them, namely quercetin, puerarin, α-lipoic acid, and curcumin, have already made their way up to clinical trials, numerous compounds have not been sufficiently investigated clinically. To develop and formulate natural antioxidant compounds as drugs against MI, it is crucial to comprehend their underlying mechanisms of cardio-protective activities and structure-activity relationships (SARs). This comprehensive review sheds light on the contribution of oxidative stress in the pathogenesis and progression of Myocardial Infarction, and highlights the cardio-protective roles of 51 natural antioxidant compounds along with their mechanistic insights and SAR.
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Alam et al. (2026) conducted a review in Oxidative stress-associated myocardial infarction. 51 plant-derived natural antioxidant compounds (including flavonoids, terpenoids, and phenolics such as quercetin, puerarin, α-lipoic acid, and curcumin) was evaluated on Cardioprotective mechanisms and structure-activity relationships (SAR) against oxidative stress-associated myocardial infarction. Fifty-one plant-derived antioxidant compounds demonstrate preclinical cardioprotective properties against myocardial infarction by mitigating oxidative stress, inflammation, apoptosis, and ferroptosis.
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