Key result
Indomethacin cuts plasma renin activity ~96% and restores angiotensin II responsiveness in Bartter's syndrome.
Why the study?
The study examined the effects of indomethacin treatment on the vascular response to angiotensin II, an angiotensin II antagonist, and a converting enzyme inhibitor in Bartter's syndrome.
Does indomethacin treatment restore altered vascular responsiveness and reduce plasma renin activity in a patient with Bartter's syndrome?
Case Report (n=1)
Does indomethacin treatment restore altered vascular responsiveness and reduce plasma renin activity in a patient with Bartter's syndrome?
Indomethacin treatment reverses the altered vascular responsiveness to angiotensin II and its inhibitors in Bartter's syndrome by correcting underlying hormonal derangements.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for indomethacin in Bartter's syndrome; prospective trials needed before clinical adoption.
The effects of indomethacin treatment on the vascular response to 5-valine-angiotensin II amide, [sarcosine, isoleucine] angiotensin II, and D-3-mercapto-2-methylpropanoyl-L-proline were examined in a patient with Bartter's syndrome. Indomethacin (150 mg/day) was administered for 5 days. PRA decreased from 74.1 to 3.2 ng/ml.h during this period. With this treatment, the normal pressor response to the synthetic angiotensin II was restored, and the hypotensive response to the angiotensin II antagonist and the converting enzyme inhibitor was markedly diminished. These results suggest that altered vascular responsiveness in Bartter's syndrome would be secondary to hormonal derangements.
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Ryushi Shimoyama (1980) conducted a case report in Bartter's syndrome (n=1). Indomethacin was evaluated on Vascular response to 5-valine-angiotensin II amide, [sarcosine, isoleucine] angiotensin II, and D-3-mercapto-2-methylpropanoyl-L-proline, and plasma renin activity (PRA). Indomethacin decreased PRA from 74.1 to 3.2 ng/ml.h and restored the normal pressor response to synthetic angiotensin II in Bartter's syndrome.
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